Laboratory Rudolf Grosschedl

Senior Group Leader and Director

Rudolf Grosschedl
phone: -711

grosschedl@immunbio.mpg.de

1952
Born in Salzburg, Austria
Undergraduate studies in Biology in Freiburg, Germany

1978
PhD  studies at University Zurich, Switzerland
Postdoctoral fellow at MIT, Cambridge, MA, USA

1986-1999
Professor at the University of California, San Francisco and
Investigator of Howard Hughes Medical Institute

1999-2004
Professor and Director of Gene Center, University of Munich, Germany

Since 2004
Director at the Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany

Project Areas

• 

  Regulatory Circuitries of B Lymphopoiesis

  Role of transcription factors in signal integration and higher-order chromatin structure. The generation of lymphocytes from hematopoietic stem cells provides...

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• 

  Stem cell pluripotency and higher-order chromatin structure

  Stem cells are unique in that they have the capacities to both self renewal and differentiation into various lineages, characteristics that may reflect the...

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Recent Publications

• Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells.
  Flach, H., Rosenbaum, M., Duchniewicz, M., Kim, S., Zhang, S.L., Cahalan, M.D., Mittler, G., Grosschedl, R. (2010)
  Immunity 33, 723-735
• Early B cell factor 2 regulates hematopoietic stem cell homeostasis in a cell-nonautonomous manner.
  Kieslinger M, Hiechinger S, Dobreva G, Consalez GG, Grosschedl R. (2010)
  Cell Stem Cell. 7, 496-507
• Structure of an Ebf1:DNA complex reveals unusual DNA recognition and structural homology with Rel proteins.
  Treiber N, Treiber T, Zocher G, Grosschedl R. (2010)
  Genes Dev. 24, 2270-2275
• Memories of lost enhancers.
  Sen, R. and Grosschedl, R. (2010)
  Genes Dev. 2, 973-979
• Early B Cell Factor 1 Regulates B Cell Gene Networks by Activation, Repression, and Transcription- Independent Poising of Chromatin.
  Treiber, T., Mandel, E.M., Pott, S., Györy, I., Firner, S., Liu, E.T. and Grosschedl, R. (2010)
  Immunity 32, 714-725
• Transcription control of early B cell differentiation.
  Mandel, E.M. and Grosschedl, R. (2010)
  Curr Opin Immunol. 22, 161-167
• Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression.
  Savarese, F., Dávila, A., Nechanitzky, R., De La Rosa-Velazquez, I., Pereira, C.F., Engelke, R., Takahashi, K., Jenuwein, T., Kohwi-Shigematsu, T., Fisher, A.G. and Grosschedl, R. (2009)
  Genes Dev. 23, 2625-2638
• Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.
  Dawlaty, M.M., Malureanu, L., Jeganathan, K.B., Kao, E., Sustmann, C., Tahk, S., Shuai, K., Grosschedl, R., van Deursen, J.M. (2008)
  Cell 133, 103-115
• Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin.
  Sustmann, C., Flach, H., Ebert, H., Eastman, Q. and Grosschedl, R. (2008)
  Mol Cell Biol. 28, 3526-3537
• Multitasking of interferon regulatory factor-4 in early B cells.
  Nielsen, P. and Grosschedl, R. (2008)
  Immunity 28, 295-297
• Satb2 regulates callosal projection neuron identity in the developing cerebral cortex.
  Alcamo, E.A., Chirivella, L., Dautzenberg, M., Dobreva, G., Fariñas, I. and Grosschedl, R. and McConnell, S.K. (2008)
  Neuron 57, 364-377
• Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5.
  Pongubala, J.M., Northrup, D.L., Lancki, D.W., Medina, K.L., Treiber, T., Bertolino, E., Thomas, M., Grosschedl, R., Allman, D. and Singh, H. (2008)
  Nat Immunol. 9, 203-215

Group Members

• Group Leader

  Grosschedl, Rudolf
  phone: -711
  grosschedl@immunbio.mpg.de
  
  

• Administrative Assistant

  Rott, Marika
  phone: -711
  rott@ie-freiburg.mpg.de
  
  

• Postdoctoral Fellows

  Andreani, Virginia
  phone: -771
  andreani@ie-freiburg.mpg.de
  
  
• Ebert, Hanna
  phone: -731
  ebert@ie-freiburg.mpg.de
  
  
• Korniychuk, Ganna
  phone: -729
  korniychuk@ie-freiburg.mpg.de
  
  
• Ramamoorthy, Senthilkumar
  phone: -731
  senthilkumar@ie-freiburg.mpg.de
  
  
• Rodriguez-Gil, Alfonso
  phone: -755
  rodriguezgil@ie-freiburg.mpg.de
  
  
• Ronzon, Sina Yvonne
  phone: -770
  ronzon@ie-freiburg.mpg.de
  
  
• Skorupa, Alexandra
  phone: -771
  skorupa@ie-freiburg.mpg.de
  
  

• Ph.D. Students

  Akbas Avci, Duygu
  phone: -731
  akbas_avci@ie-freiburg.mpg.de
  
  
• Antonio Urrutia, Gustavo
  phone: -770
  antonio@ie-freiburg.mpg.de
  
  
• Boller, Sören
  phone: -755
  boller@ie-freiburg.mpg.de
  
  
• Kapoor, Tanya
  phone: -752
  kapoor@ie-freiburg.mpg.de
  
  
• Karabacak, Aslihan
  phone: -755
  karabacak@ie-freiburg.mpg.de
  
  
• Nechanitzky, Robert
  phone: -730
  nechanitzky@ie-freiburg.mpg.de
  
  
• Phongbunchoo, Yutthaphong
  phone: -729
  phongbunchoo@ie-freiburg.mpg.de
  
  
• Rosenbaum, Marc
  phone: -753
  rosenbaum@ie-freiburg.mpg.de
  
  
• Yang, Cheng-Yuan
  phone: -755
  yangc@ie-freiburg.mpg.de
  
  

• Master Students

  Herp, Simone
  phone: -770
  herp@ie-freiburg.mpg.de
  
  
• Scherer, Stefanie
  phone: -770
  scherer@ie-freiburg.mpg.de
  
  

• Technicians

  Düring, Franziska
  phone: -771
  duering@ie-freiburg.mpg.de
  
  
• Falk, Ingrid
  phone: -718
  falk@ie-freiburg.mpg.de
  
  
• Fietze, Stefanie
  phone: -770
  fietze@ie-freiburg.mpg.de
  
  
• Krötschel, Marit
  phone: -770
  kroetschel@ie-freiburg.mpg.de
  
  

• Student Assistants

  Metzger, Philipp
  phone: -731
   
  
  
• Mühle, Jonas
  phone: -770