Laboratory Tilman Borggrefe

Group Leader

Tilman Borggrefe
phone: -715/-773

borggrefe@immunbio.mpg.de

1971
Born in Bonn, Germany
Undergraduate studies in biochemistry at the Imperial College, London, UK

1996-1999
PhD studies at the Basel Institute for Immunology, University of Basel, Switzerland

1999-2003
Postdoctoral fellow at Stanford University, San Francisco, USA

2003-2005
Junior professor and Emmy-Noether group leader in the Department of Immunology, University of Ulm, Germany

Since 2005
Group leader at the Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany

Project Areas

• 

  Transcriptional Regulation of Blood Cell Development

  Unraveling the Molecular Mechanism of the Notch Signal Transduction Pathway. During development gene expression is controlled by signal transduction pathways...

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• 

  Regulation of histone marks by Notch

  We examine Notch-based transcriptional regulation using a newly characterized pre-T cell line. We are able to show that target gene activation and repression...

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• 

  Mediator of transcriptional regulation in hematopoiesis

  All protein coding genes are transcribed by RNA polymerase II, the central enzyme in gene expression. The Mediator complex forms the bridge between...

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Recent Publications

• RITA, a novel modulator of Notch signaling, acts via nuclear export of RBP-J.
  Wacker, SA., Alvarado, C, von Wichert, G., Knippschild, U., Wiedenmann, J., Claus, K., Nienhaus, G, Hameister, H., Baumann, B., Borggrefe, T., Knöchel, W. und Oswald F. (2011)
  EMBO Journal 30, 43-56
• Specific erythroid-lineage defect in mice conditionally deficient in Mediator subunit Med1.
  Stumpf, M., Yue, X., Schmitz, S., Luche, H., Fehling, H. Reddy, J. and Borggrefe, T. (2010)
  107, 21541-21546
• Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex.
  Liefke, R., Oswald, F., Alvarado, C., Ferres-Marco, D., Mittler, G., Rodriguez, P., Dominguez, M. and Borggrefe, T. (2010)
  Genes Dev. 24, 590-601
• The Notch signaling pathway: Transcriptional regulation at Notch target genes.
  Borggrefe, T. and Oswald, F. (2009)
  Cell. and Mol. Life Sciences 66, 1631-1646
• ETO, but not leukemogenic fusion protein AML1/ETO, augments RBP-Jkappa/SHARP-mediated repression of notch target genes.
  Salat, D., Liefke, R., Wiedenmann, J., Borggrefe, T. (Corresponding authorand) Oswald, F. (2008)
  Mol Cell Biol. 10, 3502-3512

Group Members

• Group Leader

  Borggrefe, Tilman
  phone: -715 / -773
  borggrefe@ie-freiburg.mpg.de
  
  

• Ph.D. Students

  Giaimo, Benedetto Daniele
  phone: -773
  giaimo@ie-freiburg.mpg.de
  
  
• Hein, Kerstin
  phone: -773
  hein@ie-freiburg.mpg.de
  
  
• Jung, Claudia
  phone: -723 / -769
  jung@ie-freiburg.mpg.de
  
  

• Master Students

  Loyal, Lucie
  phone: -773
  loyal@ie-freiburg.mpg.de
  
  
• Röttele, Eva
  phone: -773
  roettele@ie-freiburg.mpg.de
  
  
• Schwäble, Anja
  phone: -723
  schwaeble@ie-freiburg.mpg.de
  
  

• Technicians

  Fietzeck, Sabine
  phone: -723
  fietzeck@ie-freiburg.mpg.de