Work in the Department of Developmental Immunology addresses major issues in adaptive and innate immunity. Two groups examine various aspects of immune tolerance. The Boehm group focuses on central tolerance by studying the processes underlying thymopoiesis in vertebrates. The Izcue group studies aspects of peripheral tolerance, particularly the role of regulatory T cells in intestinal immunity. Finally, the Freudenberg group investigates how pathogens are recognized by the innate immune system using the response to LPS as the paradigm.