Laboratory Thomas Jenuwein

Senior Group Leader and Director

Thomas Jenuwein
phone: -785

jenuwein@immunbio.mpg.de

1956
Born in Lohr am Main, undergraduate studies of Biology at University Erlangen, Germany

1983
PhD studies at EMBL, Heidelberg, Germany

1988-1993
Postdoctoral fellow at UCSF, San Francisco, USA

1993-2001
Group leader at the Institute of Molecular Patholohgy (IMP), Vienna, Austria

2002-2008
Senior Scientist at IMP, Vienna, Austria

Since 2008
Director at Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany

Project Areas

• 

  Epigenetic Control by Histone Methylation

  Epigenetic mechanisms control eukaryotic development beyond DNA-stored information. There are many pathways, such as DNA methylation, nucleosome remodelling,...

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• 

  Genome-wide distribution and function of the Suv39h enzymes

  Under the Austrian GEN-AU initiative (www.gen-au.at), we have performed large-scale analyses (ChIP-seq) of histone methylation marks in defined chromatin...

  more details >

Recent Publications

• Mammalian Su(var) genes in chromatin control.
  Fodor, B., Shukeir, N., Reuter, G. and Jenuwein, T. (2010)
  Annu Rev Cell Dev Biol. 26, 471-501
• Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence.
  Reimann, M., Lee, S., Loddenkemper, C., Dörr, J.R., Tabor, V., Aichele, P., Stein, H., Dörken, B., Jenuwein, T. and Schmitt C.A. (2010)
  Cancer Cell 17, 262-272
• PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation.
  Feng, W., Yonezawa, M., Ye, J., Jenuwein, T and Grummt I. (2010)
  Nat Struct Mol Biol. 17, 445-450
• G9a and Glp methylate lysine 373 in the tumor suppressor p53.
  Huang, J., Dorsey, J., Chuikov, S., Perez-Burgos, L., Zhang, X., Jenuwein, T., Reinberg, D. and Berger, S.L. (2010)
  J Biol Chem. 285, 9636-9641
• Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression.
  Savarese, F., Dávila, A., Nechanitzky, R., De La Rosa-Velazquez, I., Pereira, C.F., Engelke, R., Takahashi, K., Jenuwein, T., Kohwi-Shigematsu, T., Fisher, A.G. and Grosschedl, R. (2009)
  Genes Dev. 23, 2625-2638
• Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.
  Trojer, P., Zhang, J., Yonezawa, M., Schmidt, A., Zheng, H., Jenuwein, T. and Reinberg, D. (2009).
  J Biol Chem. 284, 8395-8405
• H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosome.
  Pauler, F.M., Sloane, M.A., Huang, R., Regha, K., Koerner, M.V., Tamir, I., Sommer, A., Aszodi, A., Jenuwein, T. and Barlow, D.P. (2009)
  Genome Res. 19, 221-33
• Di-methyl H4 lysine 20 targets the checkpoint protein Crb2 to sites of DNA damage.
  Greeson, N.T., Sengupta, R., Arida, A.R., Jenuwein, T. and Sanders, S.L.(2008)
  J Biol Chem. 283, 33168-33174
• PR-SET7 and SUV4-20H regulate H4 lysine-20 methylation at imprinting control regions in the mouse.
  Pannetier, M., Julien, E., Schotta, G., Tardat, M., Sardet, C., Jenuwein, T. and Feil, R. (2008)
  EMBO Rep. 9, 998-1005
• Moving AHEAD with an international human epigenome project.
  American Association for Cancer Research Human Epigenome Task Force; European Union, Network of Excellence, Scientific Advisory Board. (2008)
  Nature 454, 711-715
• A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.
  Schotta, G., Sengupta, R., Kubicek, S., Malin, S., Kauer, M., Callén, E., Celeste, A., Pagani, M., Opravil, S., De La Rosa-Velazquez, I.A., Espejo, A., Bedford, M.T., Nussenzweig, A., Busslinger, M. and Jenuwein, T. (2008)
  Genes Dev. 22, 2048-2061

Group Members

• Group Leader

  Jenuwein, Thomas
  phone: -785
  jenuwein@ie-freiburg.mpg.de
  
  

• Administrative Assistant

  Mare, Marcela
  phone: -574
  mare@ie-freiburg.mpg.de
  
  

• Scientific Coordinator

  Lachner, Monika
  phone: -786
  lachner@ie-freiburg.mpg.de
  
  

• Staff Scientists

  Shukeir, Nicholas
  phone: -782 / -779
  shukeir@ie-freiburg.mpg.de
  
  

• Postdoctoral Fellows

  De la Rosa, Init Alberto
  phone: -783
  delarosa@ie-freiburg.mpg.de
  
  
• Galan, Carmen
  phone: -783
  galan@ie-freiburg.mpg.de
  
  
• Van de Nobelen, Suzanne
  phone: -783
  nobelen@ie-freiburg.mpg.de
  
  

• Ph.D. Students

  Christen, Carlos Nahuel
  phone: -782
  christen@ie-freiburg.mpg.de
  
  
• Eisold, Michael
  phone: -782 / -779
  eisold@ie-freiburg.mpg.de
  
  
• Fritzsch, Christoph
  phone: -781
  fritzsch@ie-freiburg.mpg.de
  
  
• Karslioglu, Aydan
  phone: -782
  karslioglu@ie-freiburg.mpg.de
  
  
• Perrera, Valentina
  phone: -779
  perrera@ie-freiburg.mpg.de
  
  
• Pinheiro, Ines
  phone: -781
  pinheiro@ie-freiburg.mpg.de
  
  
• Velazquez, Oscar
  phone: -782
  velazquez@ie-freiburg.mpg.de
  
  

• Master Students

  Fröhlich, Jonathan
  phone: -782
  froehlich@ie-freiburg.mpg.de
  
  

• Technicians

  Engist, Bettina
  phone: -787
  engist@ie-freiburg.mpg.de
  
  
• Koschorz, Birgit
  phone: -791
  koschorz@ie-freiburg.mpg.de