Laboratory J. Andrew Pospisilik

Group Leader

J. Andrew Pospisilik
phone: -757

pospisilik@ie-freiburg.mpg.de

1976
Born in Vancouver, Canada
Undergraduate studies in Physiology at the University of British Columbia, Vancouver, Canada

2003
PhD studies at the University of British Columbia, Vanvouver, Canada

2004-2009
Postdoctoral fellow at the Institute of Molecular Biotechnology, Vienna, Austria

Since March 2010
Group Leader at the Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany

Project Areas

• 

  Epigenetic Control of Complex Disease

  Chromatin plasticity in metabolism and cancer. Introduction. Current estimates place the prevalence of diabetes and obesity in the range of 300 million to...

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• 

  Functional translation of epigenetic cues

  A compliment to the first strategy, our second long-term goal is to functionally characterize disease-specific epigenetic modifications in vivo. These studies,...

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Recent Publications

• Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat.
  Teperino, R., Amann, S., Bayer, M., McGee, S.L., Loipetzberger, A., Connor, T., Jaeger, C., Kammerer, B., Winter, L., Wiche, G., Dalgaard, K., Selvaraj, M., Gaster, M., Young, R.L., Febbraio, M.A., Knauf, C., Cani, P.D., Aberger, F., Penninger, J.M., Pospisilik, J.A.*, Esterbauer, H.E.* (2012)
  Cell 151, 414-426
• The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism.
  Haschemi, A., Kosma, P., Gille, L., Evans, C.R., Burant, C.F., Starkl, P., Knapp, B., Haas, R., Schmid, J.A., Jandl, C., Amir, S., Lubec, G., Park, J., Esterbauer, H., Bilban, M., Brizuela, L., Pospisilik, J.A., Otterbein, L.E., Wagner, O. (2012)
  Cell Metab 15, 813-826
• Variants in STAT5B associate with serum TC and LDL-C levels.
  Kornfeld, J.W., Isaacs, A., Vitart, V., Pospisilik, J.A., Meitinger, T., Gyllensten, U., Wilson, J.F., Rudan, I., Campbell, H., Penninger, J.M., Sexl, V., Moriggl, R., van Duijn, C., Pramstaller, P.P., Hicks, A.A. (2011)
  J Clin Endocrinol Metab. 96, 1496-1501
• Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.
  Mueller, K.M., Kornfeld, J.W., Friedbichler, K., Blaas, L., Egger, G., Esterbauer, H., Hasselblatt, P., Schlederer, M., Haindl, S., Wagner, K.U., Engblom, D., Haemmerle, G., Kratky, D., Sexl, V., Kenner, L., Kozlov, A.V., Terracciano, L., Zechner, R., Schuetz, G., Casanova, E., Pospisilik, J.A., Heim, M.H., Moriggl, R. (2011)
  Hepatology 54, 1398-1409
• Cross-talk between interferon-y and hedgehog signaling regulates adipogenesis.
  Todoric, J., Strobl, B., Jais, A., Boucheron, N., Bayer, M., Amann, S., Lindroos, J., Teperino, R., Prager, G., Bilban, M., Ellmeier, W., Krempler, F., Müller, M., Wagner, O., Patsch, W., Pospisilik, J.A.*, Esterbauer, H.* (2011)
  Diabetes 60, 1668-1676
• Central apelin controls glucose homeostasis via a nitric oxide-dependent pathway in mice.
  Duparc, T., Colom, A., Cani, P.D., Massaly, N., Rastrelli, S., Drougard, A., Le Gonidec, S., Moulédous, L., Frances, B., Leclercq, I., Llorens-Cortes, C., Pospisilik, J.A., Delzenne, N.M., Valet, P., Castan-Laurell, I., Knauf, C. (2011)
  Antioxid Redox Signal 16, 1477-1496
• The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression.
  Schramek, D., Kotsinas, A., Meixner, A., Wada, T., Elling, U., Pospisilik, J.A., Neely, G.G., Zwick, R.H., Sigl, V., Forni, G., Serrano, M., Gorgoulis, V.G., Penninger, J.M. (2011)
  Nat Genet. 43, 212-219
• A genome-wide Drosophila screen for heat nociception identifies ?2?3 as an evolutionarily conserved pain gene.
  Neely, G.G., Hess, A., Costigan, M., Keene, A.C., Goulas, S., Langeslag, M., Griffin, R.S., Belfer, I., Dai, F., Smith, S.B., Diatchenko, L., Gupta, V., Xia, C.P., Amann, S., Kreitz, S., Heindl-Erdmann, C., Wolz, S., Ly, C.V., Arora, S., Sarangi, R., Dan, D., Novatchkova, M., Rosenzweig, M., Gibson, D.G., Truong, D., Schramek, D., Zoranovic, T., Cronin, S.J., Angjeli, B., Brune, K., Dietzl, G., Maixner, W., Meixner, A., Thomas, W., Pospisilik, J.A., Alenius, M., Kress, M., Subramaniam, S., Garrity, P.A., Bellen, H.J., Woolf, C.J., Penninger, J.M. (2010)
  Cell 143, 628-38
• Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer.
  Schramek, D., Leibbrandt, A., Sigl, V., Kenner, L., Pospisilik, J.A., Lee, H.J., Hanada, R., Joshi, P.A., Aliprantis, A., Glimcher, L., Pasparakis, M., Khokha, R., Ormandy, C.J., Widschwendter, M., Schett, G., Penninger, J.M. (2010)
  Nature 468, 98-102
• Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet.
  Ehses, J.A., Meier, D.T., Wueest, S., Rytka, J., Boller, S., Wielinga, P.Y., Schraenen, A., Lemaire, K., Debray, S., Van Lommel, L., Pospisilik, J.A., Tschopp, O., Schultze, S.M., Malipiero, U., Esterbauer, H., Ellingsgaard, H., Rütti, S., Schuit, F.C., Lutz, T.A., Böni-Schnetzler, M., Konrad, D. and Donath, M.Y. (2010)
  Diabetologia Epub Apr21
• A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.
  Neely, G.G., Kuba, K., Cammarato, A., Isobe, K., Amann, S., Zhang, L., Murata, M., Elmén, L., Gupta, V., Arora, S., Sarangi, R., Dan, D., Fujisawa, S., Usami, T., Xia, C.P., Keene, A.C., Alayari, N.N., Yamakawa, H., Elling, U., Berger, C., Novatchkova, M., Koglgruber, R., Fukuda, K., Nishina, H., Isobe, M., Pospisilik, J.A., Imai, Y., Pfeufer, A., Hicks, A.A., Pramstaller, P.P., Subramaniam, S., Kimura, A., Ocorr, K., Bodmer, R. and Penninger, J.M. (2010)
  Cell 141, 142-53
• Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate.
  Pospisilik, J.A., Schramek, D., Schnidar, H., Cronin, S.J., Nehme, N.T., Zhang, X., Knauf, C., Cani, P.D., Aumayr, K., Todoric, J., Bayer, M., Haschemi, A., Puviindran, V., Tar, K., Orthofer, M., Neely, G.G., Dietzl, G., Manoukian, A., Funovics, M., Prager, G., Wagner, O., Ferrandon, D., Aberger, F., Hui, C.C., Esterbauer, H. and Penninger, J.M. (2010)
  Cell 140, 148-60

Group Members

• Group Leader

  Pospisilik, John Andrew
  phone: -757
  pospisilik@ie-freiburg.mpg.de
  
  

• Postdoctoral Fellows

  Gossens, Klaus
  phone: -792
  gossens@ie-freiburg.mpg.de
  
  
• Jayaramaiah Raja, Sunil
  phone: -793
  raja@ie-freiburg.mpg.de
  
  
• Lempradl, Adelheid
  phone: -757
  lempradl@ie-freiburg.mpg.de
  
  
• Öst, Anita
  phone: -793
  oest@ie-freiburg.mpg.de
  
  
• Teperino, Raffaele
  phone: -793
  teperino@ie-freiburg.mpg.de
  
  

• Ph.D. Students

  Dalgaard, Kevin
  phone: -792
  dalgaard@ie-freiburg.mpg.de
  
  
• Longinotto, John
  phone: -793
  longinotto@ie-freiburg.mpg.de
  
  
• Lu, Tsai-Hsiu
  phone: -792
  lu@ie-freiburg.mpg.de
  
  
• Selvaraj, Madhan
  phone: -793
  selvaraj@ie-freiburg.mpg.de
  
  

• Technicians

  Ruf, Marius
  phone: -792
  ruf@ie-freiburg.mpg.de
  
  

• Student Assistants

  Tran, Quyen
  phone: -792
  tran@ie-freiburg.mpg.de