Emeritus Laboratory Rolf Kemler

Senior Group Leader

Rolf Kemler
phone: -471

kemler@ie-freiburg.mpg.de

1945
born in Burghaun, Germany
studies in veterinary medicine, University Giessen, Germany

1971-1973
PhD at the Max Planck Institute of Immunobiology, Freiburg, Germany

1974-1981
Postdoctoral studies at the Institut Pasteur, Paris, France

1981-1987
Group Leader, Friedrich-Miescher-Laboratorium of the Max Planck Society in Tübingen

1987 - 1992
Group Leader at the Max Planck Institute of Immunobiology, Freiburg, Germany

Since 1992
Director at the Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany 

Project Areas

• 

  Cell Adhesion in Mouse Development (Marc Stemmler)

  Classical cadherins and their molecular function during development and differentiation – Marc Stemmler. Cadherin-mediated adhesion is crucial during...

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• 

  Post-transcriptional control of ß-catenin and N-cadherin by microRNAs and RNA-binding proteins (Jennifer Winter)

  The regulation of gene expression at the post-transcriptional level is critical to normal development and tissue homeostasis. We are examining a putative...

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• 

  The function of ß-catenin in embryonic stem (ES) cells and in development (Rolf Kemler)

  The dual role of ß-catenin in cadherin-mediated adhesion and as the downstream effector of the canonical Wnt signaling pathway is addressed by combining...

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Recent Publications

• Wnt/ß-catenin signaling regulates telomerase in stem cells and cancer cells.
  Hoffmeyer, K., Raggioli, A., Rudloff, S., Anton, R., Hierholzer, A., Del Valle, I., Hein, K., Vogt, R., Kemler, R. (2012)
  Science 336, 1549-1554
• Lineage specification of parietal epithelial cells requires ß-catenin/Wnt signaling
  Grouls S, Iglesias DM, Wentzensen N, Moeller MJ, Bouchard M, Kemler R, Goodyer P, Niggli F, Gröne HJ, Kriz W, Koesters R (2012)
  J Am Soc Nephrol. 2012 Jan;23(1):63-72
• Differential requirements for ß-catenin during mouse development
  Rudloff S, Kemler R (2012)
  Development. 2012 Oct;139(20):3711-21
• N-cadherin can structurally substitute for E-cadherin during intestinal development but leads to polyp formation.
  Libusova, L., Stemmler, M.P., Hierholzer, A., Schwarz, H. and Kemler, R. (2010)
  Development 137, 2297-2305
• Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism.
  Messerschmidt, D.M. and Kemler, R. (2010)
  Dev Biol. 344, 129-137
• Beta-catenin-mediated signaling and cell adhesion in postgastrulation mouse embryos.
  Hierholzer, A. and Kemler, R. (2010)
  Dev. Dyn. 239, 191-199
• Abrogation of E-cadherin-mediated cell-cell contact in mouse embryonic stem cells results in reversible LIF-independent self-renewal.
  Soncin, F., Mohamet, L., Eckardt, D., Ritson, S., Eastham, A.M., Bobola, N., Russell, A., Davies, S., Kemler, R., Merry, C.L. and Ward, C.M. (2010)
  Stem Cells 27, 2069-2080
• E-cadherin as a novel surface marker of spermatogonial stem cells.
  Tolkunova, E.N., Malashicheva, A.B., Chikhirzhina, E.V., Kostyleva, E.I., Zeng, W., Luo, J., Dobrinski?, I., Hierholzer, A., Kemler, R. and Tomilin, A.N. (2009)
  Tsitologiia 51, 212-218
• Cdx1::Cre allele for gene analysis in the extraembryonic ectoderm and the three germ layers of mice at mid-gastrulation.
  Hierholzer, A. and Kemler, R. (2009)
  Genesis 47, 204-209
• Neural progenitors of the postnatal and adult mouse forebrain retain the ability to self-replicate, form neurospheres, and undergo multipotent differentiation in vivo.
  Neumeister, B., Grabosch, A., Basak, O., Kemler, R. and Taylor, V. (2009)
  Stem Cells 27, 714-723
• The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development.
  Slanchev, K., Carney, T. J., Stemmler, M. P., Koschorz, B., Amsterdam, A., Schwarz, H. and Hammerschmidt, M. (2009)
  PLoS Genet 5, e1000563
• The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs.
  Wellner, U., Schubert, J., Burk, U. C., Schmalhofer, O., Zhu, F., Sonntag, A., Waldvogel, B., Vannier, C., Darling, D., zur Hausen, A., Brunton, V. G., Morton, J., Sansom, O., Schuler, J., Stemmler, M. P., Herzberger, C., Hopt, U., Keck, T., Brabletz, S., and Brabletz, T. (2009)
  Nat Cell Biol 11, 1487-1495
• Postsynaptic and differential localization to neuronal subtypes of protocadherin beta16 in the mammalian central nervous system.
  Junghans, D., Heidenreich, M., Hack, I., Taylor, V., Frotscher, M. and Kemler, R. (2008)
  Eur. J. Neurosci. 27, 559-571
• Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis.
  Koch, U., Wilson, A., Cobas, M., Kemler, R., Macdonald, H.R. and Radtke, F. (2008)
  Blood 111, 160-164
• A nonneural epithelial domain of embryonic cranial neural folds gives rise to ectomesenchyme.
  Breau, M. A., Pietri, T., Stemmler, M. P., Thiery, J. P. and Weston, J. A. (2008)
  Proc Natl Acad Sci U S A 105, 7750-7755
• Cadherins in development and cancer.
  Stemmler, M. P. (2008)
  Mol Biosyst 4, 835-850
• The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex.
  Aranda-Orgillés, B., Trockenbacher, A., Winter, J., Aigner, J., Köhler, A., Jastrzebska, E., Stahl, J., Müller, E.C., Otto, A., Wanker, E.E., Schneider, R., Schweiger, S. (2008)
  Hum Genet. 123, 163-176
• Comparative 3'UTR analysis allows identification of regulatory clusters that drive Eph/ephrin expression in cancer cell lines.
  Winter J, Roepcke S, Krause S, Müller EC, Otto A, Vingron M, Schweiger S. (2008)
  PLoS One 3, e2780

Group Members

• Group Leader

  Kemler, Rolf
  phone: -471
  kemler@ie-freiburg.mpg.de
  
  

• Administrative Assistant

  Schneider, Rosemary
  phone: -470
  schneider@ie-freiburg.mpg.de
  
  

• Staff Scientists

  Haas, Ingrid
  phone: -475
  haasi@ie-freiburg.mpg.de
  
  
• Stemmler, Marc
  phone: -477
  stemmler@ie-freiburg.mpg.de
  
  
• Winter, Jennifer
  phone: -451
  winter@ie-freiburg.mpg.de
  
  

• Postdoctoral Fellows

  Hodjat, Mahshid
  phone: -487
  hodjat@ie-freiburg.mpg.de
  
  

• Ph.D. Students

  Basilicata, Maria Felicia
  phone: -477
  basilicata@ie-freiburg.mpg.de
  
  
• Bräutigam, Christien
  phone: -473
  braeutigam@ie-freiburg.mpg.de
  
  
• Hoffmeyer, Katrin
  phone: -489 / -485 / -483
  hoffmeyer@ie-freiburg.mpg.de
  
  
• Raggioli, Angelo
  phone: -489
  raggioli@ie-freiburg.mpg.de
  
  
• Rago, Luciano
  phone: -473
  rago@ie-freiburg.mpg.de
  
  

• Technicians

  Hansen, Käthe
  phone: -477
  hansen@ie-freiburg.mpg.de
  
  
• Hierholzer, Andreas
  phone: -487
  hierholzer@ie-freiburg.mpg.de