Laboratory Michael Reth

Laboratory Michael Reth

Research of the Department of Molecular Immunology seeks to better understand the organisation and regulation of intracellular signalling pathways in normal and diseased lymphocytes. Research of the Department is traditionally focused on the B lymphocyte although recently we have extended our studies to signalling pathways in mast cells and to structure/function studies of the T cell antigen receptor. We have developed several model systems for studying protein-protein interactions between leukocyte receptors and their signalling components.

In collaboration with the University of Freiburg and the MPI, the Department organizes an advanced study of molecular immunology. This program started in 1997 and has become very popular, attracting students from Freiburg and other Universities.

University Prof. and Depart. Head

Michael Reth
phone: -421

michael.reth@bioss.uni-freiburg.de

1950
Born in Düsseldorf, Germany
Undergraduate Studies in Biology, University of Cologne

1977-1981
PhD studies at University of Cologne

1982-1985
Postdoctoral studies Columbia University, New York

1985-1988
Assistant Professor University of Cologne

1989-1996
Associate Professor Max Planck Institute of Immunobiology, Freiburg

Since 1996
Professor at the University of Freiburg, Head of the Department of Molecular Immunobiology

Since 2007
Scientific director of the Center for Biological Signalling Studies (BIOSS) funded by the excellence program of the German government

Project Areas

Signal Processes in B Cells: from Analysis to Synthesis

Synthetic Biology to decipher Structure and Function of B cell Receptor Signalling. The proper development and activation of B lymphocytes is controlled by...

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Studying B cell function in vivo with the Cre/loxP technique

The BCR signaling subunit Ig-a is required for the proper expression and function of the BCR on the B cell surface. Using the MerCreMer/loxP technique we can...

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Recent Publications

B cells that produce immunoglobulin E mediate colitis in BALB/c mice.
Hoving J.C., Kirstein F., Nieuwenhuizen N.E., Fick L.C., Hobeika E., Reth M., Brombacher F. (2011)
Gastroenterology Oct. 6, Epub ahead of print
Tp53 deletion in B lineage cells predisposes mice to lymphomas with oncogenic translocations
Rowh M.A., Demicco A., Horowitz J.E., Yin B., Yang-Iott K.S., Fusello A.M., Hobeika E., Reth M., Bassing C.H. (2011)
Oncogene May 30, Epub ahead of print
B cell homeostasis and plasma cell homing controlled by Krüppel-like factor 2.
Winkelmann R., Sandrock L., Porstner M., Roth E., Mathews M., Hobeika E., Reth M., Kahn M.L., Schuh W., Jäck H.M. (2011)
Proc Natl Acad Sci U S A 108, 710 - 715
Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor.
Heizmann B., Reth M., Infantino S. (2010)
Proc Natl Acad Sci U S A 107, 18563-18568
The dissociation activation model of B cell antigen receptor triggering.
Yang J., Reth M. (2010)
FEBS Lett. 584, 4872-4877
Oligomeric organization of the B-cell antigen receptor on resting cells.
Yang J., Reth M. (2010)
Nature 467, 465-469
N-linked glycosylation selectively regulates autonomous precursor BCR function.
Ubelhart R., Bach M.P., Eschbach C., Wossning T., Reth M., Jumaa H. (2010)
Nat Immunol. 11, 759-765
Analysis of novel phospho-ITAM specific antibodies in a S2 reconstitution system for TCR-CD3 signalling.
Dopfer E.P., Schöpf B., Louis-Dit-Sully C., Dengler E., Höhne K., Klescová A., Prouza M., Suchanek M., Reth M., Schamel W.W. (2010)
Immunol Lett. 130, 43-50
Voltage control for B cell activation.
Reth, M. and Dick, T.P. (2010)
Nat. Immunol. 11, 191-192
Arginine methylation of the B-cell antigen receptor promotes differentiation.
Infantino, S., Benz, B., Waldmann, T., Jung, M., Schneider, R., and Reth, M. (2010)
J.Exp.Med. 207, 711-719
Autoinhibition and adapter function of Syk.
Kulathu, Y., Grothe, G., and Reth, M. (2009)
Immunol Rev. 232, 286-299
Regulation of B-cell proliferation and differentiation by pre-B cell receptor signalling.
Herzog, S., Reth, M., and Jumaa, H. (2009)
Nat Rev Immunol. 9, 195-205
Genomic instability resulting from Blm deficiency compromises development, maintenance, and function of the B cell lineage.
Babbe, H., McMenamin, J., Hobeika, E., Wang, J., Rodig, SJ., Reth, M., and Leder P. (2009)
J Immunol 182, 347-360

Group Members

Group Leader

Reth, Michael

phone: -421

reth@ie-freiburg.mpg.de
Administrative Assistant

Vitt, Miriam

phone: -420

officer@ie-freiburg.mpg.de
Project Leader

Hobeika, Elias

phone: -422

hobeika@ie-freiburg.mpg.de
Yang, Jianying

phone: -427

yang@ie-freiburg.mpg.de
Postdoctoral Fellows

Maity, Palash

phone: -425

maity@ie-freiburg.mpg.de
Medgyesi, David

phone: -433 / -436

medgyesi@ie-freiburg.mpg.de
Salavei, Pavel

phone: -427

salavei@ie-freiburg.mpg.de
Ph.D. Students

Alsadeq, Ameera

phone: -436

alsadeq@ie-freiburg.mpg.de
Brenker, Kathrin

phone: -425

brenker@ie-freiburg.mpg.de
Brings, Naema

phone: -433 / -436

brings@ie-freiburg.mpg.de
Dolezal, Elmar

phone: -433

dolezal@ie-freiburg.mpg.de
Kläsener, Kathrin

phone: -425

klaesener@ie-freiburg.mpg.de
Levit, Ella

phone: -422

levit@ie-freiburg.mpg.de
Volkmann, Christoph

phone: -427

volkmann@ie-freiburg.mpg.de
Master Students

Altmeier, Simon

phone: -422

altmeier@ie-freiburg.mpg.de
Grishin, Denis

phone: -436

grishin@ie-freiburg.mpg.de
Research Assistants

Becker, Annabelle

phone: -422

becker@ie-freiburg.mpg.de
Pohlmeyer, Roland

phone: -422

pohlmeyer@ie-freiburg.mpg.de
Technicians

Kalmbach-Zuern, Christa

phone: -433

zuern@ie-freiburg.mpg.de
Student Assistants

Börsig, Theresa

phone: -436

boersig@ie-freiburg.mpg.de
Krause, Arndt

phone: -433

krause@ie-freiburg.mpg.de

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