Laboratory Peter Nielsen

We are interested in the regulation of gene expression during B-cell development. We are studying the influence of the transcriptional activator protein Bob1/OBF1/OCA-B in pre B-cells. In a second project, we examine the effect of somatic recombinations in the immunoglobulin kappa locus on immunoglobulin lambda recombination.

Group Leader

Peter Nielsen
phone: -319

nielsen@ie-freiburg.mpg.de

1952
Born in Minnesota, USA
Undergraduate studies in Biology at the Colorado School of Mines and Western State College, Colorado, USA

1975-1980
PhD studies at the Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado

1980-1982
Postdoctoral fellow at the Friedrich Miescher Institute, Basel, Switzerland

1982-1985
Postdoctoral fellow at the Biozentrum, University of Basel, Basel, Switzerland

Since 1985
Group leader at the Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany

Project Areas

Gene Expression during B-cell Development

Who’s on when? B cells are derived from hematopoietic stem cells found mostly in the bone marrow of adult mammals or in the liver during fetal development....

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The role of Bob1 in regulating B-cell development

We are also studying Bob1 (also known as OCA-B and OBF-1), a 34 Kd protein originally identified as a transcriptional co-activator expressed at varying levels...

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